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이혜아 ( Lee Hye-Ah ) - 이화여자대학교 의학전문대학원 예방의학교실
박은혜 ( Park Eun-Ae ) - 이화여자대학교 의학전문대학원 소아과학교실
김영주 ( Kim Young-Ju ) - 이화여자대학교 의학전문대학원 산부인과학교실
이화영 ( Lee Hwa-Young ) - 이화여자대학교 의학전문대학원 해부학교실
홍영선 ( Hong Young-Sun ) - 이화여자대학교 의학전문대학원 내과학교실
장남수 ( Chang Nam-Soo ) - 이화여자대학교 건강과학대학 식품영양학과
오세용 ( Oh Se-Young ) - 경희대학교 생활과학대학 식품영양학과
하은희 ( Ha Eun-Hee ) - 이화여자대학교 의학전문대학원 예방의학교실
박혜숙 ( Park Hye-Sook ) - 이화여자대학교 의학전문대학원 예방의학교실
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Abstract
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Objectives: Woman with low pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) associated with restricted prenatal growth and offspring"s obesity, respectively. In present study, we aim to show the interaction effect of pre-pregnancy BMI and GWG on childhood overweight in 3 years of age.
Methods: We followed up subjects in Ewha Birth & Growth Cohort, which is a prospective cohort established 2001-2005. The study subjects consisted of 214 who had informed pre-pregnancy BMI and GWG and theirs offspring participated in the regular examination at 3 years of age. Anthropometric measurements and whole blood sample were done at 3 years of age. The interaction effect of the pre-pregnancy BMI and GWG has been estimated using ANCOVA.
Results: Pre-pregnancy BMI categories were assigned the values of low-weight (≤=18.5㎏/㎡), normal weight (18.6~22.9㎏/㎡), and high weight (＞23.0㎏/㎡) according to the Asia - Pacific standard and GWG was categorized in three group under weight gain, normal weight gain, and over weight gain using gestational weight gain inter r quartiles range according to gestational age. Our study shows that low pre-pregnancy BMI and high pre-pregnancy BMI groups have higher standardized weight at 3 years of age compared to normal pre-pregnancy BMI group. Moreover, pre-pregnancy BMI interacted with gestational weight gain in birth weight (p＜0.04) and standardized weight at 3 years of age (p＜0.01) when adjusted for maternal age and offspring gender.
Conclusions : This study shows that low pre-pregnancy BMI and under GWG are associated with offspring"s high weight at early childhood. Therefore, we suggest that it is important for women to maintain normal range of BMI and GWG in pre-pregnancy and pregnancy.
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KeyWords
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pre-pregnancy body mass index, gestational weight gain, children, overweight
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원문 및 링크아웃 정보
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등재저널 정보
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